Can Oregano Oil Help Prevent Antibiotic Resistance? (2024)

Can Oregano Oil Help Prevent Antibiotic Resistance? (1)

Designed specifically for fighting bacterial infections, antibiotics are one of medical doctors’ favorite tools for treating many health issues. There’s another underutilized natural “medicine” that many doctors don’t tell their patients about: oregano oil (also called oil of oregano).

Oregano oil has proven to be a powerful, plant-derived essential oil that may rival antibiotics when it comes to treating or preventing various infections. In fact, it contains properties that are antibacterial, antiviral and antifungal.

In addition, oregano essential oil is unlikely to cause many of the harmful side effects that are commonly attributed to high use of antibiotics — such as increased risk for antibiotic resistance, poor gut health due to destroying beneficial probiotic bacteria, reduced vitamin absorption and leaky gut syndrome due to damage of the gastrointestinal tract’s lining.

Meanwhile, oregano oil benefits extend beyond just controlling infections. What else is oregano essential oil used to treat?

Common examples of conditions that oregano oil can help manage include:

  • Athlete’s foot or toenail fungus
  • Common colds
  • Gingivitis
  • Earaches or toothaches
  • Digestive problems, such as heartburn and small intestine bacterial overgrowth (SIBO)

What Is Oregano Oil?

Oregano (Origanum vulgare)is an herb that is a member of the mint family (Labiatae). It has been considered a precious plant commodity for over 2,500 years in folk medicines that originated across the globe.

It has a very long use in traditional medicine for treating colds, indigestion and upset stomachs.

You might have some experience cooking with fresh or dried oregano leaves — such as oregano spice, one of the top herbs for healing — but oregano essential oil is far from what you’d put in your pizza sauce.

Found in the Mediterranean, throughout many parts of Europe, and in South and Central Asia, medicinal grade oregano is distilled to extract the essential oilfrom the herb, which is where a high concentration of the herb’s active constituents are found. It takes over 1,000 pounds of wild oregano to produce just one pound of oregano essential oil, in fact.

The oil’s active ingredients are preserved in alcohol and used in essential oil form both topically (on the skin) and internally.

When made into a medicinal supplement or essential oil, oregano is often called “oil of oregano.” As mentioned above, oregano oil is a considered a natural alternative to prescription antibiotics.

Oil of oregano contains two powerful compounds called carvacrol and thymol, both of which have been shown in studies to have strong antibacterial and antifungal properties.

Oregano’s oil is primarily made of carvacrol, while studies show that the plant’s leaves contain a variety of antioxidant compounds, such as phenols, triterpenes, rosmarinic acid, ursolic acid and oleanolic acid.

Can Oregano Oil Help Prevent Antibiotic Resistance? (2)

Oregano Oil Benefits

What can you use oregano essential oil for? The predominant healing compound found in oregano oil, carvacrol, has widespread uses ranging from treating allergies to protecting the skin. The Faculty of Pharmacy at the University of Messina in Italy reports that:

Carvacrol, a monoterpenic phenol, has emerged for its wide spectrum activity extended to food spoilage or pathogenic fungi, yeast and bacteria as well as human, animal and plant pathogenic microorganisms including drug-resistant and biofilm forming microorganisms.

Carcavol found in oregano essential oil is so potent that it has been been the focus of over 800 studies referenced in PubMed, the world’s No. 1 database for scientific evidence-based literature. To give you a sense of how multi-functional and impressive carvacrol is, it has been shown in studies to help reverse or reduce some of these common health problems:

  • Bacterial infections
  • Fungal infections
  • Parasites
  • Viruses
  • Inflammation
  • Allergies
  • Tumors
  • Indigestion
  • Candida

Here’s a look at the top health benefits of oregano oil:

1. Natural Alternative to Antibiotics

What’s the problem with frequently using antibiotics? Broad-spectrum antibiotics can be dangerous because they don’t only kill bacteria that are responsible for infections, but they also kill good bacteria that we need for optimal health.

In 2013, the Wall Street Journal printed a fantastic article highlighting the dangers that patients may face when they repeatedly use antibiotics. In the author’s words, “Recent studies have shown that doctors are overprescribing broad-spectrum antibiotics, sometimes called the big guns, that kill a wide swath of both good and bad bacteria in the body.”

Overuse of antibiotics, and prescribing broad-spectrum drugs when they aren’t needed, can cause a range of problems. It can make the drugs less effective against the bacteria they are intended to treat by fostering the growth of antibiotic-resistant infections, and it can wipe out the body’s good bacteria (probiotics), which help digest food, produce vitamins and protect from infections, among other functions.

Unfortunately, broad-spectrum antibiotics are very commonly prescribed, often for conditions in which they have no use, such as viral infections. In one study published in the Journal of Antimicrobial Chemotherapy, researchers from the University of Utah and the Center for Disease Control and Prevention found that 60 percent of the time when physicians prescribe antibiotics they choose broad-spectrum types.

A similar study of children, published in the journal Pediatrics,found that when antibiotics were prescribed they were broad-spectrum 50 percent of the time, mainly for respiratory conditions.

In contrast, what does oil of oregano do for you that makes it so beneficial?Essentially, taking oregano oil is a “broad-spectrum approach” to protecting your health.

Its active ingredients help fight multiple types of harmful pathogens, including bacteria, yeast and fungi. As a study in theJournal of Medicinal Food journal stated in 2013, oregano oils “represent an inexpensive source of natural antibacterial substances that exhibited potential for use in pathogenic systems.”

2. Fights Infections and Bacterial Overgrowth

Here’s the good news regarding the use of less-than-ideal antibiotics: There’s evidence that oregano essential oil can help fight at least several strains of bacteria that cause health problems that are commonly treated with antibiotics.

Here are some highlights of the ways oregano oil benefits these conditions:

  • Dozens of studies confirm the fact that oregano oil can be used in place of harmful antibiotics for a number of health concerns.
  • In 2011, the Journal of Medicinal Food published a study that evaluated the antibacterial activity of oregano oil against five different types of bad bacteria. After evaluating the antibacterial characteristics of oil of oregano, it showed significant antibacterial properties against all five species. The highest activity was observed against E. Coli, which suggests that oregano oil could potentially be routinely used to promote gastrointestinal health and prevent deadly food poisoning.
  • A 2013 study published in Journal of the Science of Food and Agriculture concluded that “O. vulgare extracts and essential oil from Portuguese origin are strong candidates to replace synthetic chemicals used by the industry.” Researchers from the study found that after studying the antioxidant and antibacterial properties of oregano, Origanum vulgare inhibited the growth of seven tested strains of bacteria that other plant extracts could not.
  • One study involving mice that was published in the journal Revista Brasileira de Farmacognosia also found impressive results. In addition to fighting bacteria like listeria and E. coli, researchers also found evidence that oregano oil may have the ability to help pathogenic fungi.
  • Other evidence shows that oregano oil’s active compounds (such as thymol and carvacrol) can help fight toothaches and earaches caused by bacterial infections. A 2005 study published in the Journal of Infectious Diseases concluded,“Essential oils or their components placed in the ear canal can provide effective treatment of acute otitis media.”

3. Helps Reduce Side Effects From Medications/Drugs

In recent years, many studies have found that one of the most promising oregano oil benefits is helping reduce side effects from medications/drugs. These studies give hope to people who want to find a way to manage the horrible suffering that accompanies drugs and medical interventions, such as chemotherapy or use of drugs for chronic conditions like arthritis.

A study published in the International Journal of Clinical and Experimental Medicineshowed that phenols in oil of oregano can help protect against methotrexate toxicity in mice.

Methotrexate (MTX) is a drug commonly used to treat a wide array of issues from cancer to rheumatoid arthritis, but it’s also well-known to have dangerous side effects. After evaluating oil of oregano’s ability to keep these factors at bay, researchers believe it’s due to oregano’s antioxidants and anti-inflammatory properties.

Oregano was shown to work better than drugs that are ineffective at providing full protection against MTX’s adverse effects.

By evaluating various markers in the sciatic nerve in mice, it was observed for the first time that carvacrol decreased the pro-inflammatory response in mice being treated by MTX. Being a relatively new concept in the research world, it’s likely that there will be more studies testing these results because “groundbreaking” doesn’t even begin to describe the significance of this potential oregano health benefit.

Similarly, research conducted in the Netherlands showed that oregano essential oil can also “prevent bacterial overgrowth and colonization in the large intestine during oral iron therapy.” Used to treat iron deficiency anemia, oral iron therapy is known to cause a series of gastrointestinal issues like nausea, diarrhea, constipation, heartburn and vomiting.

It’s believed that carvacrol targets the outer membrane of gram-negative bacteria and increases membrane permeability, thereby causing depletion of harmful bacteria. In addition to its antimicrobial properties, carvacrol also interferences with certain pathways for bacterial iron handling, which helps lower side effects of iron therapy.

Can Oregano Oil Help Prevent Antibiotic Resistance? (3)

4. Helps Treat Athlete’s Foot

One study found that a combination of heat, salt and use of essential oils (including oregano) had inhibitory effects against mycelia of T. rubrum and conidia of T. mentagrophytes, bacterial strains that commonly cause the fungal infection known asathlete’s foot.

The researchers concluded that thermotherapy combined with essential oils and salt would be promising to treat tinea pedis in a foot bath. After testing the fungicidal activity of 11 essential oils against the bacteria known to cause athlete’s foot, oregano oil was found to be the most powerful (followed by thyme, cinnamon bark, lemongrass and clove).

5. Helps Treat Digestive Issues (Including SIBO and Heartburn)

Several of the active compounds found in Origanum vulgare can help aid digestion by relaxing the muscles of the GI tract and also helping balance the ratio of good-to-bad bacteria in the gut.

Thymol, one of oregano’s active compounds, is a similar compound to menthol, which is found in peppermint oil. Like menthol, thymol may help relax the soft tissue of the throat and stomach, which can help to decrease GERD, heartburn and discomfort after eating.

Because it helps balance bacteria and fights yeast overgrowth, oregano essential oil is also a popular natural treatment for candida and SIBO. SIBO is a common digestive problem that causes gas, bloating and intolerances to many carbohydrate-containing foods (especially FODMAPs).

Origanum vulgare hinders bacterial replication and can be used similarly to antibiotic medications, such as rifaximin (Xifaxan), for treating infections that affect digestive health and nutrient absorption.

A 2014 studypublished inGlobal Advances in Health & Medicinefound evidence that use of herbal antimicrobials is just as effective as the antibiotic usually given for the treatment of SIBO. When 104 patients diagnosed with SIBO (via lactulose breath test) were treated either with rifaximin (1,200 milligrams) or herbal antimicrobials over the course of four weeks, the results showed that 46 percent of the patients treated with herbal antimicrobials experienced symptom improvements compared to only 34 percent treated with the antibiotic rifaximin.

Additionally, 14 of the 44 patients who still had SIBO after a course of rifaximin were then treated with herbal antimicrobials. Fifty-seven percent responded positively to the herbal treatment even after failing to feel better from the antibiotics.

6. Can Help Treat Parasites

One study found that when adults whose stools tested positive for enteric parasites (including Blastocystis hominis, which causes digestive distress) supplemented with 600 milligrams of oregano for six weeks, many experienced significant improvements in gastrointestinal symptoms.

Researchers reported a complete disappearance of Entamoeba hartmanni (four cases), Endolimax nana (one case) and Blastocystis hominis in eight cases. Gastrointestinal symptoms improved in seven of the 11 patients who tested positive for Blastocystis hominis, which tends to cause symptoms like nausea, gas, bloating and abdominal pain.

7. Helpful for Managing Inflammatory Conditions (such as IBD or Rheumatism)

Oregano retains its strong antioxidant capacity in both fresh and dry form. Due to its high concentration of antioxidants, oregano essential oil has been shown to help reduce oxidative damage and help in preventing mutagenesis, carcinogenesis and aging due its free radical scavenging activities.

Free radicals are believed to be a contributing factor to common chronic conditions, including cancer, cardiovascular diseases, neurodegenerative disorders and drug toxicity.

One study found that combined treatment with thyme and oregano essential oils helped reduce the production of pro-inflammatory cytokines and thereby may help attenuate colitis (a type of inflammatory bowel disease) in mice.

Other studies show that oregano oil is beneficial for treating reoccurring respiratory disorders, tumor growth and rheumatoid arthritis. Research from the Universidad Nacional de Córdoba in Argentina indicates that essential oil isolated from Origanum vulgare “presents antibacterial, antioxidant and chemopreventive properties and could be play an important role as bioprotector agent.”

8. May Help Improve Cholesterol Levels

Research published in theJournal of International Medical Research suggests that adding oregano oil supplementation can improve cholesterol levels.

For the study, 48 patients with mild hyperlipidemia were given lifestyle and low-fat dietary advice. Thirty-two of the patients (study group) were prescribed 25 milliliters of oregano distillate to be taken after each meal for three months, and the remaining 16 patients were the control group.

After the three-month study period, those in the study group showed significantly greater increases in high-density lipoprotein (HDL) cholesterol and significantly greater decreases in low density lipoprotein (LDL) cholesterol compared to the control group.

How to Use

Oregano oil can be used topically, diffused or taken internally (only if it’s 100 percent therapeutic grade oil). Ideally, you purchase 100 percent pure, unfiltered, Certified USDA Organic oregano oil.

It’s also available as oregano oil soft gels or capsules to take internally.

Before using oregano essential oil on your skin, always mix it with a carrier oil, such as coconut oil or jojoba oil. This helps reduce the risk for irritation and adverse reactions by diluting the oil.

To use it topically, mix three drops of undiluted oregano oil with a small amount of your carrier oil, and then apply topically by rubbing into the skin over the affected area.

Oregano oil uses:

  • Natural Antibiotic: Dilute it with a carrier oil, and apply it topically to the soles of your feet or take it internally for 10 days at a time and then cycle off.
  • Battle Candida and Fungal Overgrowth: For toenail fungus, you can make a homemadeantifungal powderthat can be applied to your skin. Combine the ingredients with about 3 drops of oregano oil, stir and then sprinkle the powder onto your feet. For internal use, take 2 to 4 drops twice daily for up to 10 days.
  • Fight Pneumonia and Bronchitis: For external infections, apply 2 to 3 diluted drops to the affected area. To prevent internal bacterial overgrowth, ingest 2 to 4 drops twice daily for up to 10 days.
  • Fight MRSA and Staph Infection: Add 3 drops of oregano oil to a capsule or to the food or beverage of your choice along with a carrier oil. Take it twice daily for up to 10 days.
  • Fight Intestinal Worms and Parasites: Take oregano oil internally for up to 10 days.
  • Help Remove Warts: Make sure to dilute it with another oil or mix it with clay.
  • Cleanse Mold From the Home: Add 5 to 7 drops to a homemade cleaning solution along with tea tree oil and lavender.

How much oregano essential oil to take internally:

  • Your oil of oregano dosage will depend on the condition you’re treating. In capsule form, oral supplementation of emulsified oregano is typically around 600 milligrams daily. (Either taken in one or two doses.)
  • A traditional use of oregano leaves is making digestive-aid tea. You can buy pre-made oregano tea or make your own by steeping 15 grams of oregano leaves in 250 milliliters of water for at least five–10 minutes (or longer to make a stronger herbal infusion, up to 24 hours).
  • Because oregano oil might interfere with other medications, always ask your doctor if it’s safe to take internally depending on your specific situation.

Risks, Side Effects and Interactions

You may be asking: What limits does oil of oregano have? At this point, it’s not perfectly clear.

I personally take oregano essential oil internally for a maximum of two weeks in most cases because it’s so powerful. When taking oregano oil internally, it should always be diluted with water or mixed with coconut oil.

I find it’s helpful to combine oregano oil with olive oil in capsules to avoid burning the throat. To prevent negative skin reactions from oregano application, it’s recommended that you perform a small patch test first and always use a carrier oil.

The dried herb oregano is typically fine for pregnant women, but generally speaking, it’s not considered safe to use oregano oil during pregnancy. When using oil of oregano, pregnant women should use caution and only use if instructed by their physicians to do so.

If side effects such as nausea, dizziness or an allergic reaction are ever experienced, stop using oregano oil right away, and consider seeing a doctor.

Conclusion

  • Oregano (Origanum vulgare)is an herb used to make oil of oregano, which has antioxidant, anti-inflammatory and antimicrobial properties.
  • Oregano oil health benefits include fighting bacterial infections, fungal infections, digestive problems, inflammatory conditions and tumor growth.
  • Oil of oregano can be used on the skin (such as to treat athlete’s foot or nail fungus), diffused or taken internally (such as to aid digestion and help promote gut health).
Can Oregano Oil Help Prevent Antibiotic Resistance? (2024)

FAQs

Can oregano oil replace antibiotics? ›

As a natural alternative to prescription antibiotics, oregano oil is often known as “oil of oregano.” In studies, Carvacrol and thymol, found in oregano oil, have been shown to possess potent antibacterial and antifungal properties.

What essential oils are good for antibiotic resistant bacteria? ›

Antibiotic resistance is on the rise, as is antibacterial overkill that leads to more bad bacteria spreading. Thankfully, antibacterial essential oils can help avoid this. The top four antibacterial essential oils are cinnamon, thyme, oregano and tea tree oils.

Can bacteria become resistant to oregano oil? ›

While efficiently inactivating bacteria, there was no evidence of resistance development after up to 20 consecutive passages of representative bacterial strains in the presence of sublethal doses of oregano oil.

How can we reduce antibiotic resistance naturally? ›

Food ingredients and nutrients such as thyme, mushrooms, ginger, garlic, sage, zinc, echinacea, elderberry, andrographis and pelargonium are examples of natural remedies that have been demonstrated to enhance immunity.

Is oil of oregano better than antibiotics? ›

Several studies have shown the powerful antibacterial properties of oregano oil, even against antibiotic-resistant strains of bacteria. In one study that tested the antibacterial effects of a range of essential oils, oregano oil was found to be the best at hindering bacterial growth.

What happens if you take oregano oil daily? ›

In large doses, oregano oil may be toxic -- and even lethal. Oregano may have diuretic effects. Large amounts of oregano can upset the stomach. Oregano oil may cause rash when applied to the skin.

What to do if bacteria is resistant to all antibiotics? ›

If an infection shows signs of antibiotic resistance, your healthcare provider may try a different drug. The new drug may have more severe side effects, and trying a different antibiotic also raises the risk of developing resistance to that drug.

How do you treat a resistant bacterial infection? ›

A person with a carbapenem-resistant Enterobacteriaceae infection may be treated with specialized antibiotics such as tigecycline, polymyxin B, and beta-lactam combination antibiotics. Medication may be needed only for a short period or for as long as six to eight weeks.

What are 3 methods bacteria can use to be resistant to antibiotics? ›

The three fundamental mechanisms of antimicrobial resistance are (1) enzymatic degradation of antibacterial drugs, (2) alteration of bacterial proteins that are antimicrobial targets, and (3) changes in membrane permeability to antibiotics.

What happens if you take oil of oregano for too long? ›

Risks and side effects

Taking too much of it can be harmful. One of its phenols, thymol, may contribute to this. Thrymol is a mild irritant that might affect the skin or internal organs in high doses. One potential side effect of oregano oil is gastrointestinal upset.

Does oil of oregano destroy good bacteria? ›

The answer is, no, oregano oil does not kill any good bacteria. When we use oregano for bacterial infection, it only kills those harmful to our health. Oregano has been used to treat sinus and respiratory problems for ages. Doctors used this herb to treat different diseases before the invention of modern medicines.

Is oregano oil antiviral or antibacterial? ›

Essential oils of oregano are widely recognized for their antimicrobial activity, as well as their antiviral and antifungal properties. Nevertheless, recent investigations have demonstrated that these compounds are also potent antioxidant, anti-inflammatory, antidiabetic and cancer suppressor agents.

What can reverse antibiotic resistance? ›

“Our findings show that by targeting disulfide bond formation and protein folding, it is possible to reverse antibiotic resistance across several major pathogens and resistance mechanisms.

How do you reverse antibiotic resistance? ›

Antibiotic resistance can be reversed by the addition of resistance breakers (orange boxes) such as (i) β-lactamase inhibitors to prevent antibiotic degradation; (ii) efflux pump inhibitors to allow the antibiotic to reach its target instead of being removed by the efflux pump; (iii-a) OM permeabilisers that ...

What is being done to stop antibiotic resistance? ›

The best way to prevent antibiotic resistance is to use antibiotics correctly. Take them only when needed.

What types of bacterial infections does oregano oil cure? ›

Research shows that carvacrol is effective in eliminating the bacteria Staphylococcus aureus and Staphylococcus epidermidis, two common causes of infection. Taking oregano oil supplements or rubbing it on the skin may help a person make use of these antibacterial effects.

How long can you take oregano oil? ›

Green also cautions against using oregano oil for longer than one week. Take one dose three times a day for the first two days, she suggests. Then use one capsule twice a day. If you get no relief from your symptoms after seven days, discontinue its use and find another remedy.

Is Oil of Oregano like a natural antibiotic? ›

One natural antibiotic currently being explored is oregano. Essential oils of oregano and thyme have shown antibiotic properties against various strands of bacteria through their components of carvacrol and its isomer thymol.

How many times a week should I take oregano oil? ›

Oregano oil uses:

For internal use, take 2 to 4 drops twice daily for up to 10 days. Fight Pneumonia and Bronchitis: For external infections, apply 2 to 3 diluted drops to the affected area. To prevent internal bacterial overgrowth, ingest 2 to 4 drops twice daily for up to 10 days.

Does Oil of Oregano boost immune system? ›

The most abundant phenol in oregano, it has been shown to stop the growth of several different types of bacteria ( 3 ). Thymol. This natural antifungal can also support the immune system and protect against toxins ( 4 ).

Does oil of oregano interact with any medications? ›

Interactions. With drugs: Oil of oregano may reduce the amount platelets clump together (platelet aggregation) and may reduce the way other blood clotting factors work. Oil of oregano may increase the risk of bleeding in patients taking anticoagulant/antiplatelet drugs.

How much oregano oil to take as antibiotic? ›

She suggests just 50 to 80 milligrams (two or three drops) per dose. Stick to formulas with at least 80 percent carvacrol, and take only those that are clearly labeled for medicinal use. Green also cautions against using oregano oil for longer than one week.

Is oil of oregano like a natural antibiotic? ›

One natural antibiotic currently being explored is oregano. Essential oils of oregano and thyme have shown antibiotic properties against various strands of bacteria through their components of carvacrol and its isomer thymol.

Can you get rid of a bacterial infection without antibiotics? ›

Antibiotics are only needed for treating certain infections caused by bacteria, but even some bacterial infections get better without antibiotics.

How long can you safely take oregano oil? ›

It's important not to exceed the recommended dosage given or to take oregano oil in any form, including on the skin, for more than several weeks.

What does oregano do for lungs? ›

When used in aromatherapy, Oregano Essential Oil can boost the immune system and improve the efficiency of the respiratory tract by loosening up and eliminating a buildup of mucus and phlegm. It can also soothe throat irritation to suppress coughing fits.

Does oregano oil interact with any medications? ›

Taking oregano along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely. Oregano might slow blood clotting. Taking oregano along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

What kills infection besides antibiotics? ›

Seven best natural antibiotics
  • Garlic. Cultures across the world have long recognized garlic for its preventive and curative powers. ...
  • Honey. Since the time of Aristotle, honey has been used as an ointment that helps wounds to heal and prevents or draws out infection. ...
  • Ginger. ...
  • Echinacea. ...
  • Goldenseal. ...
  • Clove. ...
  • Oregano.

What is the most powerful natural antibiotic? ›

Garlic: contains the most powerful natural antibiotic “allicin“. Due to its antiviral effect, garlic can fight harmful bacteria, viruses and fungi. It also has a mild blood thinning and blood pressure lowering effect, which can be beneficial for cardiovascular diseases.

What kills bacteria other than antibiotics? ›

The most promising alternatives include antimicrobial proteins, bacteriophages, probiotics, and plant-based substances. Each described group of substances is efficient against specific foodborne bacteria and has a preferred use in an explicit application.

What are the side effects of oregano? ›

Mild side effects include stomach upset. Oregano might also cause an allergic reaction in people who have an allergy to plants in the Lamiaceae family. Oregano oil should not be applied to the skin in concentrations greater than 1% as this might cause irritation.

What is a natural antibiotic? ›

Certain plant extracts, essential oils, and even foods have antibiotic properties. For example, some food and vegetable extracts can prevent the growth of bacteria in food. This includesgarlic, honey, and certain herbs.

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